Pictures 2006

The 2007 McKim Conference reviewed the paradigm shift that is needed to improve the efficiency of hazard assessment and the role of chemical categories in beginning a transition to the hypothesis-driven paradigm. Further, the conference examined the IQF conceptual framework for predictive toxicology and the new QSAR models for estrogen receptor binding. Finally, the conference discussed the integration of QSAR and system biology as an approach for identifying the key molecular initiating events needed to predict the hazards of chemicals.

Although the conference was intended to discuss new approaches rather than publish scientific papers. However, the conferees were unanimous that the concepts presented and discussed in Duluth should be put in writing for the benefit of larger audiences. Accordingly, the last day of the conference outlined six papers which will be written in the next six months and circulated to the participants for comment. Specifically, papers under preparation at this time include:
  • A QSAR Model for Inhalation Toxicity of Narcotics in
    Rodents and Fish
  • The use of Solubility as a Reference Point in Hazard Identification
  • Case Studies of the Use of Chemical Categories in Hazard Identification
  • A Categories Model for ER Binding Affinity
  • The Conceptual Framework for Toxicity Pathways
  • Integration of QSAR and Systems Biology within the Pathways Framework
Watch the news section on for announcements of manuscript availability.