Program 2012



Tuesday May 8, 2012
09:00 AM Welcome & Introductions
Gilman Veith, International QSAR Foundation, Two Harbors, MN
09:15 AM Review of 2010 Workshop Discussions: Aligning the domains of in vitro tests and QSAR models for identification of potential carcinogens
Gilman Veith, International QSAR Foundation, Two Harbors, MN
09:45 AM Highlighting the need for AOPs in streamlining hazard assessment methods
Kate Willett, Regulatory Toxicology, Risk Assessment and Alternatives, The Humane Society of the United States, Washington DC
09:45 AM Overview of regulatory contexts in US EPA for identification of chemicals of concern with respect to carcinogenicity
Vicki Dellarco, Office of Pesticide Programs, US EPA Washington DC
10:30 AM Coffee Break
10:45 AM Health Canada experiences with early identification of potential carcinogens
Sunil Kulkarni , Hazard Methodology Division, Existing Substances Risk Assessment Bureau Health Canada, Ottawa ON
11:30 AM In silico, in vitro, and in vivo methods as alternatives to the carcinogenicity bioassay for genotoxic chemicals
Romualdo Benigni, Experimental and Computational Carcinogenesis Unit, Istituto Superiore di Sanita, Rome, Italy
12:15 AM Lunch (catered)


1:15 PM An overview of integration of DNA profilers, metabolism and test data in the QSAR Toolbox
Ovanes Mekenyan, Laboratory of Mathematical Chemistry, Prof. Asen. Zlatarov University, Bourgas, Bulgaria
2:15 PM An evaluation of the QSAR Toolbox profilers for identifying DNA reactive and genotoxic chemicals
Terry Schultz, Professor Emeritus University of Tennessee and OECD Secretariat, Paris
3:00 PM Simulating metabolic activation of proelectrophiles in profiling
Ovanes Mekenyan, Laboratory of Mathematical Chemistry, Prof. AS. Zlatarov University, Bourgas, Bulgaria
3:30 PM Coffee Break
3:45 PM Summarizing the decision tree for identifying genotoxic chemicals
Gilman Veith, International QSAR Foundation, Two Harbors, MN
4:00 PM Overview of major mechanisms of nongenotoxic carcinogenesis and exploration of possible (Q)SAR
Yin-tak Woo, Senior Toxicologist, Office of Pollution Prevention and Toxics, USEPA, Washington DC
5:00 PM Adjourn
  Dinner on your own


Wednesday May 9,2012
09:00 AM Advances for nongenotoxic carcinogens in cell transformation
Paule Vasseur, Laboratoire Interactions, Ecotoxicologie, Biodiversité, Ecosystèmes, University of Metz, France
09:45 AM In silico, in vitro, and in vivo methods as alternatives to the carcinogenicity bioassay for epigenetic chemicals
Romualdo Benigni, Experimental and Computational Carcinogenesis Unit, Istituto Superiore di Sanita, Rome, Italy
10:30 AM Coffee Break
10:45 AM Identifying  non-genotoxic carcinogens based on mechanisms
Jan van Benthem, Department of Carcinogenesis, Mutagenesis and Reproductive Toxicology, National Institute of Public Health and the Environment, Bilthoven, The Netherlands
11:30 AM The role of signal transduction pathways in epigenetic carcinogenesis
Elizabeth Wattenberg, School of Public Health, University of Minnesota, Minneapolis MN
12:15 AM Lunch (catered)


1:15 PM Oxidative stress and Cell transformation
Marie-Aline Maire, Institut National de Recherche et de Sécurité, Vandoeuvre Les Nancy, France
2:00 PM General Discussion
All
3:30 PM Coffee Break
3:45 PM Potential role for endocrine disruptor expert systems in investigating endocrine system - epigenome interactions
Patricia Schmieder, Molecular and Cellular Mechanisms Branch, US EPA, Duluth MN
5:00 PM Adjourn
Dinner in Small Groups


Thursday May 10,2012
9:00 AM Discussion of the prospects for tiered screening methods to reduce reliance on the rodent carcinogen assay
All
10:30 AM Coffee Break
10:45 AM Workshop summary and implementing next steps
12:00 AM Lunch (catered)