Program 2010

Tuesday, May 18, 2010
6:00 PM With a number of participants are arriving Monday and early Tuesday, we will host an informal get-acquainted social near the lobby of the Canal Park Lodge

Wednesday May 19, 2010
9:00 AM Welcome & Introductions
Gilman Veith,IQF, Two Harbors
9:15 AM Review of purpose and the agenda
Gilman Veith,IQF, Two Harbors
9:50 AM Levels of Assessment in the Canadian Environmental Protection Act
Kathy Hughes, Health Canada, Ottawa
10:30 AM Coffee Break
10:45 AM In silico, in vitro, and in vivo methods as alternatives to the carcinogenicity bioassay
Romualdo Benigni, Instituto Superiore di Sanita, Rome, Italy
11:45 AM Predicting cancer endpoints using MultiCase
Gilles Klopman, MultiCase Inc, Cleveland
12:15 AM Lunch (catered)

1:15 PM Identifying genotoxic and nongenotoxic carcinogens with cell transformation assays
Paule Vasseur, Laboratoire Interactions, Ecotoxicologie, Biodiversité, Ecosystèmes, University of Metz, France
2:00 PM Identifying major stress pathways
Ram Ramabhadran, Integrative Systems Toxicology, USEPA, RTP
2:45 PM Identifying carcinogens using Oncologic
Yin-tak Woo, USEPA, Washington DC
3:30 PM Coffee Break
3:45 PM In Silico Methods for Predicting Chromasomal Endpoints
Jay Niemela, National Food Institute, Technical University of Denmark
4:30 PM Integrating Adverse Outcome Pathways into the OECD (Q)SAR Application Toolbox
Terry Schultz, OECD, Paris
5:15 PM Adjourn
7:00 PM Dinner after a short walk to Bellisio’s – (Order off the regular menu)

Thursday May 20,2010
09:00 AM Forming Chemical Categories for Cancer Endpoints
Ovanes Mekenyan, Laboratory of Mathematical Chemistry, Bourgas
09:45 AM Discussion of grouping methods that combine structural alerts and reactivity models
10:30 AM Coffee Break
10:45 AM Discussion of the predictability of metabolism, mutagenicity and cell transformation within chemical categories
12:15 AM Lunch (catered)

1:15 PM Discussion of approaches for identifying nongenotoxic pathways to carcinogenesis
3:15 PM Coffee Break
3:30 PM Discussion of “negative carcinogens” in the assessment process (QSAR boundaries for the precautionary principle in multiple pathways
5:00 PM Adjourn
7:00 PM Dinner in Small Groups

Friday May 21,2010
9:00 AM Discussion of approaches for bridging the in vitro/in vivo gap
10:30 AM Coffee Break
10:45 AM Workshop summary and implementing next steps
12:40 AM Adjourn - Lunch in Small Groups and Head to the Airport