Program 2008



Monday, September 15, 2008
Registration
6:00 PM Registration - The Inn on Lake Superior (Northern Lights Room)
7:00 PM Social (catered) - The Inn on Lake Superior (Northern Lights Room)


Tuesday, September 16 - Northern Lights Room
Using Toxicity Pathways Models in Predictive Toxicology
9:00 AM Welcome
Carl Richards, Director EPA Mid-Continent Ecology Division, Duluth, MN
9:10 AM REACH, risk assessment and the need for a change in mind set
Kees van Leeuwen, TNO Quality of Life, Zeist, The Netherlands
9:40 AM A Framework for Building Toxicity Pathways to Complex Endpoints
Gilman Veith, International QSAR Foundation, Duluth, MN
10:10 AM Status of the Glutathione Reactivity Database for Skin Sensitisation
Terry Schultz, Professor Emeritus, University of Tennessee, Knoxville, TN and OECD, Paris, FR
10:30 AM Coffee Break
10:45 AM Estimating Human Health Endpoints with the QSAR Application Toolbox
Ovanes Mekenyan, Laboratory of Mathematical Chemistry, Bourgas, Bulgaria
11:10 AM Progress Report from the IQF Consortium for Skin Sensitization Models
Mike Comber, Mike Comber Consulting, Bruxelles, Belgium
11:45 AM A Visualization Tool for Integrating Complex Toxicity Pathways
Hristo Aladjov, International QSAR Foundation, Duluth, MN
12:30 AM Lunch (catered)

Mitochondrial Targets as a Model for Organizing Molecular Initiating Events in Organelles
1:30 PM Predicting In Vivo Toxicity from In Vitro Data
James McKim IV, CeeTox Corp, Kalamazoo, MI
2:10 PM Overview of Mitochondrial Bioenergetics & Molecular Biology
Kendall Wallace, Biochemistry & Molecular Biology, University of Minnesota Medical School, Duluth. MN
2:50 PM Clinical Phenotype of Mitochondrial Disease
Charles Hoppel, Case Western Reserve University School of Medicine, Cleveland, OH
3:30 PM Coffee Break
3:45 PM QSAR Features for Inhibitors of Mitochondrial Bioenergetics
Anatoly Starkov, Weill Medical College Cornell University, New York, NY
4:15 PM Mechanisms of Mitochondrial-Mediated Cell Injury
Peter O'Brien, Professor Emeritus, Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
5:00 PM Adjourn
6:30 PM Dinner at the Great Lakes Aquarium (catered)


Wednesday, September 17 - (Northern Lights Room)
Mitochondrial Targets as a Model for Organizing Molecular Initiating Events in Organelles
9:00 AM Metabolomic & Molecular Markers of Mitochondrial Toxicity
Kendall Wallace Biochemistry & Molecular Biology, University of Minnesota Medical School, Duluth, MN
9:40 AM A Review of QSAR Models for Mitochondrial Effects in BioLoom
Albert Leo, BioByte Corp, Claremont, CA
10:15 AM Coffee Break
10:45 AM Discussion of Chemical Targets in Mitochondria
Gilman Veith, International QSAR Foundation, Duluth, MN
12:00 AM Lunch (catered)

Delineating Toxicity Pathways for Development and Reproduction
1:00 PM Delineating Toxicity Pathways for ER Mediated Effects
Patricia Schmieder, U.S. EPA, Mid-Continent Ecology Division, Duluth, MN
2:00 PM Focusing on the Adverse Outcomes of ER-mediated Pathways
Rodney Johnson, U.S. EPA, Mid-Continent Ecology Division, Duluth, MN
3:00 PM Coffee Break
3:30 PM Delineating Thyroid-Mediated Toxicity Pathways
Michael Hornung, U.S. EPA, Mid-Continent Ecology Division, Duluth, MN
4:15 PM Thyroid-mediated CNS Dysfunction
Kevin Crofton, U.S EPA, Neurotoxicology Division, Research Triangle Park, NC
5:00 PM Adjourn
7:00 PM Dinner in Small Groups



Thursday, September 18- Eagle Harbor Room
Delineating Toxicity Pathways for Neurological Endpoints
This session will exemplify attempts to link molecular targets to adverse outcomes in the nervous system, identifying evidence for toxicity pathways and critical gaps in those pathways. Emergent themes include issues of reversibility, life-stage susceptibility, dose, and links to human disease.

9:00 AM Delineating Toxicity Pathways of Peripheral Neuropathy
David Herr, U.S EPA, Neurotoxicology Division, Research Triangle Park, NC
9:40 AM Inhibition and Morphogenic Pathways Involving AChE
Steve Brimijoin, Department of Molecular Pharmacology, Mayo Clinic College of Medicine, Rochester, MN
10:20 AM Coffee Break
10:40 AM Toxicity Pathways Mediated by Ion Channels
Philip Bushnell U.S EPA, Neurotoxicology Division, Research Triangle Park, NC
11:20 AM Stress Pathways
Steve Simmons, U.S EPA, Neurotoxicology Division, Research Triangle Park, NC
12:00 AM General Discussion
Gilman Veith, International QSAR Foundation, Duluth, MN
12:40 AM Adjourn - Lunch in Small Groups and Head to the Airport


Adaption of Pathways Visualization Tools for Strategic Planning
1:30 PM For those leaving on later flights, an informal session is planned to discuss practical examples of how a toxicity pathways database can be populated with piecewise information and used to direct researchers to critical gaps in predictive toxicology.