Program 2006

June 26, 2006
6:00 PM Registration - Fitger's Inn (600 East Superior Street)
7:00 PM Social - Fireside Room at Fitger's Inn

June 27, 2006
General Plenary Session (Open to the Public)
9:00 AM Celebration of Jim McKim's Career
Welcome - Carl Richards, Director (EPA Mid-Continent Ecology Division)
9:10 AM Understanding the "Why" in Effects Research
(A Synopsis of Jim's Accomplishments) - Gilman Veith
9:40 AM A Son's Perspective
James McKim, Jr. and Michael McKim
10:30 AM Coffee Break
11:00 AM Plumbing 101 for Rat and Fish Models
Mel Andersen
11:20 AM The McKim Approach to Measuring and Modeling Metabolism
Greg Lien, Rick Kolanczyk
11:40 AM Comments from other colleagues
12:00 AM Lunch

Risk Assessment 2026
1:00 PM The Paradigm Shift in Risk Assessment
Steve Bradbury, Kees van Leeuwen
1:40 PM Water Quality Criteria: Implications for Testing
Russell Erickson
2:00 PM Toxicity Pathways to Assessment Endpoints
Pat Schmieder
2:30 PM Intrinsic Toxicity and Molecular Initiating Events
Gilman Veith
2:45 PM Coffee Break
3:15 PM The Big Questions for Endocrine Disruption
John Sumpter
3:45 PM A Systems-Based Approach for the Identification of Toxicity Pathways Associated with the HPG axis
Gary Ankley
4:15 PM Designing a QSAR Model for ER binding
Pat Schmieder
4:45 PM A Systems Approach to Characterizing and Predicting Thyroid Toxicity
Sig Degitz, Joe Tietge
5:15 PM Adjourn
6:00 PM Dinner Cruise on the Vista Queen

June 28, 2006
Chemical Extrapolations - QSAR
9:00 AM Report from the Knoxville Reactive Toxicity Workshop
Terry Schultz, Kendall Wallace
9:40 AM Narcosis and Baseline Toxicity
Larry Brooke, Chihae Yang
10:15 AM Coffee Break
10:45 AM ECOTOX: A Foundation for Extrapolation
Chris Russom
11:30 AM Read-a-Cross Methods
Joop Hermens
12:00 AM Lunch

Species-Species Extrapolations
1:00 PM Dose-Extrapolation Models
Mel Andersen, Greg Lien
1:45 PM Metabolism in Bioaccumulation Models
John Nichols
2:30 PM Species Extrapolation with PBPK Models
Krishnan Kannan
3:00 PM Coffee Break
3:30 PM Predicting Metabolites and Metabolic Activation
Saby Dimitrov
4:00 PM Measuring Metabolic Pathways and Activation
Rick Kolanczyk
4:30 PM Inhalation Toxicity in Fish and Rodents
Gilman Veith, Kendall Wallace
5:00 PM Adjourn
7:00 PM Dinner in Small Groups

June 29, 2006
Hazard Identification
9:30 AM Exposure Assesment in invitro Assays
Joop Hermens
10:00 AM Hazard Identification using QSAR Libraries
Albert Leo, David Hoekman